BPC-157 has a larger number of published studies specifically using the BPC-157 sequence (100+ papers)
Retrieved 20 February 2020
For example, older people frequently have a problem with low acid levels in their stomachs
"It also can happen in adults when somebody is extremely stressed or they're maybe having a lot of difficulty with sleep schedule, changes or disruptions to their sleep." Other conditions, like sleep apnea, can lead to irregular sleep or sleep deprivation, and that may progress to a night terror, according to McGlinchey

The combination is most useful for patients with one or more of the following: BMI of 30 or higher , or BMI 27 with at least one weight-related condition such as type 2 diabetes, hypertension, or sleep apnea History of fatigue, low mood, or brain fog on previous diets or weight loss attempts Metformin use for type 2 diabetes or pre-diabetes (chronic metformin reduces B12) Long-term proton pump inhibitor use such as omeprazole, pantoprazole, or lansoprazole Vegetarian or vegan diet with limited animal protein intake Adults over 50 , where B12 absorption naturally declines Active strength training or higher physical demands while on a calorie deficit Patients who dont fit any of these profiles can still take semaglutide alone, then add B12 if symptoms suggest it