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sALS and fALS share several features, including protein aggregation, motor neuron hyperexcitability, trafficking defects, disruption of nucleocytoplasmic transport, oxidative stress, mitochondrial dysfunction, glutamate excitotoxicity, and neuroinflammation
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Kim KY, Kim DS, Lee SK, Lee IK, Kang JH, Chang YS, Jacobs DR, Steffes M, Lee DH
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[3] Intramuscular injection, or more specifically peri-lesional injection near an injured tendon or joint, has been used in animal models to test whether local delivery produces superior effects compared to systemic dosing
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