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Resistance training: the non-negotiable foundation Strength training at least three times per week preserves muscle mass during caloric deficit more effectively than any supplement, peptide, or dietary strategy

AD mice were treated with exendin-4 with or without compound C to inhibit AMPK activity

Picking peptides that complement each other makes a difference

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These findings have implications for obesity drug development and suggest that strategies need to be developed that not only target ARC AgRP/NPY or POMC neurons