why is glutathione called gsh The synthesis of (GSH), also known as Glutathione Synthase - an overview

The following circumstances results in a high demand for glutathione and can rapidly deplete its levels due to oxidative stress and increased strain on our detoxification systems: Exposure to air pollution Toxic environmental chemicals Mold and mycotoxins Medications High stress Infections These factors are largely unavoidable in modern life leaving our cells vulnerable to oxidative free radicals and overwhelming our liver

Furthermore, ROS-mediated ER stress is linked to the onset of apoptosis

Wstner, S

The model was first fitted to the training concentrations (37.5 and 25 M doxorubicin), and then used to simulate the test concentrations (50, 12.5 and 10 M doxorubicin) as a means of blind validation, showing good accordance between the experimental and in silico outputs for all concentrations of doxorubicin

Biological activities of selected peptides: skin penetration ability of copper-peptide complexes