After replacement of previous drugs, either oral or subcutaneous semaglutide were mostly associated to metformin in dual therapy (43.5% and 46.1%, respectively), followed by the association to metformin and basal insulin (14.5% and 18.5%, respectively), without significant differences between the two formulations
GLP-1, GIP/GLP-1, and GCGR/GLP-1 receptor agonists: novel therapeutic agents for metabolic dysfunction-associated steatohepatitis
Digested products ( GSTA1 CC: 400 bp, GSTA1 CT: 400 bp + 308 bp + 92 bp and GSTA1 TT: 308 bp + 92 bp) were visualized on Chemidoc (Biorad, Hercules, CA, USA )
The drugs GI side effects, nausea, vomiting, diarrhea, constipation, can be severe in the early weeks
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