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These observations disclose a combined mechanism that uses conserved residues for ligand recognition and specific barcodes to accommodate conformations unique to each receptor, leading to a highly potent and balanced unimolecular triple agonist for GIPR, GLP-1R and GCGR 14 with a cAMP signaling potency similar to that of GIP, GLP-1 and GCG (Fig

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Role of Zinc (Zn) in Human Reproduction: A Journey from Initial Spermatogenesis to Childbirth