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In conditions like chronic inflammation or cancer, the altered activity of the PPP can significantly affect macrophage function, either promoting or suppressing inflammation (He et al., 2021
In vitro experiments were performed after 48 h and 7 days of doxy treatment
Studies treating mild to moderate B12 deficiency in older people have failed to provide cognitive benefits: A clinical trial from the Netherlands measured the cognitive response to B12 supplements in people 70 years old with mild B12 deficiency and MMA levels 320 nmol/l (average: ~450 nmol/l)
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