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Long-term use of certain medications such as metformin and proton pump inhibitors (PPIs) also increases the risk of B12 deficiency

Adjust dose, wait 1-2 weeks to assess, then consider other changes if needed

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This is research-context reference only, not a human-dosing recommendation

People with cancer (active or suspected): As mentioned previously, TB4 and TB-500 can promote the growth of new blood vessels, which could support the growth or spread of cancer.36 Professional athletes: TB4 and TB-500 are banned by the World Anti-Doping Agency (WADA)