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gradual titration (4-week intervals) significantly reduced GI discomfort compared to rapid escalation [6]
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Our findings are relevant to a previous network meta-analysis that evaluated multiple types of glucose lowering drugs in patients with type 2 diabetes with HbA 1c as the endpoint and concluded that GLP-1RAs were the most effective in lowering HbA 1c concentrations.6 Therefore, our study went further to explore among various GLP-1RA drugs which one works the best, compare the efficiency variation between different doses, and access safety profiles
For semaglutide, the majority of GI side effects are mild to moderate in severity and of short duration
Some fraction may cross the sublingual mucosa, but the amount that reaches systemic circulation intact is not clinically predictable or consistent across patients
