most of these patients present in the neonatal period with feeding difficulties, failure to thrive, neurologic deterioration, megaloblastic anemia, variable renal and liver failure, cardiomyopathy, pneumonia, and retinopathy
For neuropathy applications where ARA-290's unique properties matter most, the investment may prove worthwhile
In an ideal pH environment, the B12 can release from haptocorrin and bind to an important protein called intrinsic factor
One of the main selling points they are using on that site is the needle is "thinner" and therefore less painful
No human studies have assessed chronic administration effects on brain structure, function, or neurotransmitter systems