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Common Side Effects Most people who take GLP-1 medications experience mild digestive symptoms that often improve over time: Nausea: The most frequently reported side effect Diarrhea: Usually temporary as your body adjusts Stomach upset: Can be reduced by eating smaller meals Loss of appetite: This is actually part of how the medication works Serious but Rare Side Effects Some side effects are uncommon but require immediate medical attention: Thyroid tumors: Reported in less than 1 percent of patients Gallbladder problems: Including gallstones in some patients Severe stomach pain: Could indicate pancreatitis Kidney problems: Especially if you become dehydrated Patients should discuss all potential risks with their healthcare provider before starting any GLP-1 medication