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2023) and has shown its action on diabetic peripheral neuropathy and has helped in attenuating the development of allodynia and hyperalgesia in STZ model of DNP by inhibiting microglial activation and also by decreasing the inflammatory mediators and oxidative stress (Abo-Salem 2014)
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If you can deliver the same drug only into the cells where you want PPAR activation (the metabolically-active cells expressing GLP-1R or GIPR) and leave the rest of the bodys PPARs untouched, you have a chance of breaking the side-effect ceiling that has limited the entire class for two decades
Disclose use to your GP or pharmacist without delay, and seek urgent medical attention via NHS 111 or 999 if you experience severe abdominal pain, persistent vomiting, dehydration, or symptoms of low blood sugar
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