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As the body of literature on this topic expands, more refined clinical guidance for the use of GLP-1RAs is expected to emerge
Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids [published correction appears in J Am Diet Assoc
The ACHIEVE-3 study enrolled 1,698 adults with type 2 diabetes inadequately controlled on metformin and compared two doses of Foundayo with approved doses of oral semaglutide over 52 weeks. At the highest dose comparison, Foundayo 17.2 mg reduced A1C by an average of 2.2% from a baseline of 8.3%, compared with a 1.4% reduction for oral semaglutide 14 mg. The difference represented a 57.1% greater relative reduction in A1C. "ACHIEVE-3 provides the first head-to-head data on oral GLP-1s in type 2 diabetes, with orforglipron showing greater A1C and weight reductions than oral semaglutide." Julio Rosenstock, MD The treatment also produced greater weight loss
There are several other important factors to consider
