Pharmacovigilance refinement using MedDRA + Re-run disproportionality analyses with (a) Standardised MedDRA Queries where applicable, (b) stratification by reporter type (healthcare professional vs consumer), co-medication filters (exclude SGLT2), and time-to-onset modelling to separate early dehydration-linked symptoms from later endocrine/tissue changes
This gap highlights the need for mechanistic frameworks that explain how chronic drug exposure interacts with stress and mood-related circuits
Semaglutide targets appetite and metabolism rather than removing fat
People with higher baseline body fat percentages often have greater insulin resistance, altered incretin signaling, and blunted hormonal responses
Theres no better evidence now than before the FDA made its announcement that peptides have any of the claimed effects, we don't know what they do, and there are still all the concerns about compounding pharmacies complying with good manufacturing practices that already exist, she says