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What the Numbers Show Average weight loss by timepoint: Week 12: 8.7% total body weight (19 pounds for 220-pound person) Week 24: 17.3% total body weight (38 pounds for 220-pound person) Week 36: 21.1% total body weight (46 pounds for 220-pound person) Week 48: 24.2% total body weight (53 pounds for 220-pound person) Data from Phase 2 clinical trial, 12mg dose cohort

Additionally, cumulative BrAC calculated using area under the curve (AUC) was reduced in the GLP-1RA group as compared to the control group ((F(1,14) = 9.36, p = 0.008, f = 0.82)

Taking two doses close together or doubling up on doses is not recommended and can increase side effects

Risk of insomnia attributable to -blockers in elderly patients with newly diagnosed hypertension

Int J Environ Res Public Health