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North Carolina eliminated GLP-1 coverage beginning October 2025 due to a budget stalemate in the legislature, but coverage was reinstated in December 2025, bringing the total number of states covering GLP-1s for obesity to 13 as of January 2026

While NP4 remained relatively stable under physiological conditions, the payload was readily released in the presence of H 2 O 2 (Supplementary Fig

Rather than creating negative consequences for drinking or simply blocking certain receptors, triple-agonist medications like Retatrutide appear to fundamentally shift how the brain experiences and pursues rewards