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Concomitantly, clinical and experimental observations 70,71 have revealed that endogenous estrogens can protect against IR primarily through ER- activation in multiple tissues, including in the brain, liver, skeletal muscle, and adipose tissue, in addition to pancreatic cells

Prediger, M

In mouse model, A distinctive pathological feature of ALS is the mislocalization and aggregation of phosphorylated TDP-43 (pTDP-43), a nuclear RNA-binding protein encoded by TARDBP

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Proteins were digested into peptides using a high-throughput automated version of the protein aggregation capture workflow 52 on the KingFisher Flex Purification System (Thermo Fisher Scientific)