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Excessive iron accumulation in the brain intensifies oxidative stress, amplifies lipid peroxidation, and promotes ferroptosis, thereby accelerating neuronal degeneration (Zhang et al., 2024)

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GLP-1 receptor agonists (GLP-1RAs) are widely used in the treatment of type 2 diabetes (T2DM) due to their attributes such as body weight loss, protection of islet cells, promotion of islet cell proliferation, and minimal side effects