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Furthermore, cytokines such as TNF- and interferon-gamma have been shown to induce extrinsic apoptosis in melanocytes in addition to ROS

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The absorbance decrease is measured at 340 nm

H&E staining results further confirmed that the aortic wall thickness of mice treated with FOXO4-DRI was significantly thinner, and ultrasound examination results showed that the PWV of the aorta was slowed down after FOXO4-DRI treatment, indicating better vascular elasticity and significantly improved vascular function compared to the control group (Figures 2D,E)