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To date, intracellular hyper-phosphorylated tau protein accumulation (neurofibrillary tangles) and extracellular A deposition (senile plaques) in brain parenchyma is considered the central neuropathological hallmarks of the disease (Selkoe and Hardy, 2016)
Basic activities like bathing or dressing become painful
Fatty acid oxidation and photoreceptor metabolic needs
Ellsworth, K
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