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Through -glucuronidase activity, gut microbes deconjugate bound androgens, increasing circulating free testosterone levels (70)

In a typical encapsulation experiment, PLGA nanoparticles exhibited a hydrodynamic diameter of 170 30 nm (z-average, PDI = 0.162) as measured using dynamic light scattering with anionic effective surface charge (20.5 5.3 mV) due to the terminal carboxylate groups on the PLGA polymers

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The SURMOUNT trials found no signal for life-threatening rhythm disturbances across 6,600+ participants over 72 weeks

It is the most cost-effective option for patients who will progress through the full titration schedule