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Given that immune cell accumulation plays a vital role in eye diseases pathogenesis, previous researchers have also studied the effect of GLP-1RAs on macrophages and discovered that it could reduce macrophage infiltration in addition to altering macrophage phenotypes in multiple sclerosis and nephropathy (Chiou et al., 2019

Until then, Retatrutide remains in the experimental stage, and its dosage is still under investigation

Common transient side effects include mild-to-moderate gastrointestinal events (nausea, diarrhea, vomiting, constipation) that typically diminish with time and proper titration

But efficacy is only one aspect of the clinical assessment of the retatrutide vs