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The activation of these receptors in the hippocampus, a region crucial for memory formation, is believed to enhance synaptic plasticity and neurogenesis, providing a direct biological basis for the cognitive-enhancing effects observed in preclinical studies (During et al., 2003)

SIRT1 induces the recruitment of DNA repair factors, including NBS1 and Rad51, in keratinocytes to maintain genome stability and gene transcription

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Pioglitazone therapy in progressive differentiated thyroid carcinoma