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In animal models, TB-500 increased re-epithelialization rates and accelerated wound closure compared to placebo controls.- Clinical trials with thymosin beta-4 analogues showed improved outcomes in patients with chronic pressure ulcers.- BPC-157 studies demonstrated higher collagen deposition, angiogenesis, and granulation tissue formation in injured tissue models

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However, REDEFINE 4 (Feb 2026) found CagriSema did not meet noninferiority versus tirzepatide 15 mg at 84 weeks