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has suggested that combined inhibition of endogenous antioxidant GSH and thioredoxin antioxidant pathways can produce a synergistic anti-cancer effect both in vitro and in vivo (264)
In contrast, exposure to environmental heavy metals can increase glutathione in amphibian tissues (59), perhaps contributing to increased survival in metal disease refuges (60)
Some patients also experience reduced appetite for warm foods or soups, further decreasing their natural heat generation
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