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Carmines E, Gaworski C (2005) Toxicological evaluation of glycerin as a cigarette ingredient

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Some degree of increased cold sensitivity may persist in individuals who achieve substantial weight loss due to reduced insulating adipose tissue

Safety: What is and is not known Animal safety data A 2020 preclinical safety evaluation by Xu and colleagues in Regulatory Toxicology and Pharmacology examined BPC-157 across multiple species mice, rats, rabbits, and dogs and reported no serious toxicity, no genotoxicity, and no embryotoxicity at doses evaluated