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This is the most critical prevention window

The biphasic response suggests possible mechanisms: lower doses (nanogram range) might work through growth factor upregulation and signaling cascade amplification, while higher doses (microgram range) might involve direct receptor activation or substrate provision for cellular repair

Studies have shown that phytonutrients such as quercetin and curcumin as well as N-acetyl cysteine and omega 3 fatty acids can attenuate neuroinflammation by supporting anti-inflammatory pathways as well as acting as antioxidants

This distinction is important because while blocking COX-2 provides the anti-inflammatory benefits, blocking COX-1 can lead to side effects like stomach problems (Daniels et al., 2016

It's given as an intramuscular injection, not an IV infusion, and is prepared by a compounding pharmacy rather than manufactured as a standardized pharmaceutical product