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In diet-induced obese (DIO) mouse models, 5-Amino-1MQ treatment produced significant reductions in body weight, white adipose tissue mass, and adipocyte cell size without significant effects on food intake suggesting a metabolic rather than appetite-suppressing mechanism
What they found: Mean weight loss: 2.6 kg vs 2.3 kg placebo , a difference of only 0.3 kg (1 %) Statistically non-significant Clinically unsatisfactory for the obesity indication Safety profile remained favorable Why it matters: The study stopped the development of AOD-9604 as a drug
Unfortunately, there are a few problems with this particular skinny shot as well
People often ask whether phentermine is a GLP-1 , and the answer illustrates just how different these drug classes are in both mechanism and safety profile
N Engl J Med 2015;372:1832-43
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