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While clinical trials show significant average weight loss with FDA-approved GLP-1 medications, results are not guaranteed and compounded formulations have not been evaluated in the same clinical trial framework

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Indeed, neurotrophic factors applied nasally pass the BBB and reach relevant concentrations in the CNS by this method of application (141),

Like Saxenda, Wegovy is FDA-approved for chronic weight management in adults with a BMI of 30 or higher or those with a BMI of 27 or higher who have at least one weight-related condition like high cholesterol, high blood pressure, or prediabetes

A comprehensive summary of CHAC1 expression across tumor types, along with TP53 status and ferroptosis susceptibility, is provided in Supplementary Table S1