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Darkening of skin is a relatively common problem

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Genetics plays a role here, and people who have genetically lower IgE levels are less likely to have chronic urticaria.[ref] Mast cells, atrial fibrillation, and cardiac diseases: Researchers estimate that there are ~50,000 mast cells/g of human heart tissue

Consistent use for at least 3 months will yield visible skin whitening and anti-aging effects

doi:10.1093/clinchem/47.8.1467

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