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Dawkins says, Since the GIP [glucose-dependent insulinotropic polypeptide] hormone acts as an antiemetic, the dual agonist tirzepitide is associated with fewer adverse side effects and better tolerance. References 1

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Science 299(5611):14101413 Cuello F, Knaust AE, Saleem U, Loos M, Raabe J, Mosqueira D, Laufer S, Schweizer M, van der Kraak P, Flenner F, Ulmer BM, Braren I, Yin X, Theofilatos K, Ruiz-Orera J, Patone G, Klampe B, Schulze T, Piasecki A, Pinto Y, Vink A, Hbner N, Harding S, Mayr M, Denning C, Eschenhagen T, Hansen A (2021) Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation

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In the liver, a particular metabolic pathway called transsulfuration permits the supply of cysteine by conversion of an essential amino acid: methionine

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