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Both peptides are generally considered well-tolerated in preclinical studies, but mild injection-site reactions, nausea, dizziness, or rare allergic responses have been reported

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Unlike native amylin, which has an extremely short half-life of minutes, cagrilintide has been engineered for once-weekly subcutaneous administration through strategic amino acid substitutions and fatty acid acylation

B12 is essential for red blood cell formation, neurological function, and DNA synthesis