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The Department of Health and Social Care (DHSC) has warned that the shortage of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) will continue, with supply not expected to return to normal until at least the end of 2024
I.PichiriG.PiluduM.FaisS.OrruG.CongiuT.et al (2022)
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Proc Natl Acad Sci U S A 100:14381443 Lee Y, Wang MY, Du XQ, Charron MJ, Unger RH (2011) Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice
Thus, there is considerable protein synthesis during cystine starvation which depletes amino acids and causes a reduction in mTORC1 signaling
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