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A 2020 meta-analysis of 37 randomized controlled trials with over 2,200 participants found that L-carnitine supplementation led to an average weight loss of 1.21 kg, a slight drop in BMI, and a reduction in fat mass by about 2.08 kg, especially in people with overweight or obesity

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The primary function of the GLP-1R is to bind the GLP-1 protein and its analogs and initiate signaling inside pancreatic -cells to release insulin

In humans it is synthesised by the gene GLP1R , which is present on chromosome 6