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Alzheimers disease manifests through reduced beneficial bacteria including Bifidobacterium and elevated opportunistic pathogens such as Escherichia and Clostridium ( 253, 254)

This indication is not approved by the FDA, even though use for this purpose may be relatively common

Lesions can also occur on the lower trunk and thigh

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The inhibition of Na + reabsorption thus, prevents the normally associated K + efflux to the lumen, hence the potassium-sparing effects of these drugs