Other ACTIVITY GOAL This article reviews the mechanisms by which NMDA receptor dysfunction might lead to the complex patterns of symptoms and neurocognitive deficits seen in schizophrenia and on methods by which glutamate-based theories can be used to develop new treatment methodologies
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Its main function is antioxidant activity
Intracellular ROS elevated by concurrent inhibition of the Nrf2 and CD44v9 pathways promotes p38 MAPK activation and modulates the expression or activity of cell cycle regulators, including cyclin D1, the cyclin-dependent kinase inhibitors (CDKI
The copper component also serves as a cofactor for superoxide dismutase (SOD-1 and SOD-3), providing direct antioxidant protection at the tissue level