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However, at higher than physiologic pH levels, the stimulation of hexokinase and phosphofructokinase activity merely results in the accumulation of fructose diphosphate and triosephosphates, because the availability of nicotinamide adenine dinucleotide (NAD) + for the glyceraldehyde phosphate dehydrogenase (GAPDH) reaction becomes a limiting factor

Initial treatment with fixed-dose combination rosiglitazone/glimepiride in patients with previously untreated type 2 diabetes

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Trends in glioblastoma: outcomes over time and type of intervention: a systematic evidence based analysis