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As for nephroprotection, an RCT on the use of febuxostat vs topiroxostat show none improvement in urinary protein/creatinine ratio
They are referenced here only as examples of broadly accepted analytical and impurity-control principles
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Also advising to keep them at 2 weekly at that stage
Make sure patients understand exactly what off-label use means, what risks and benefits there are, and what the alternatives look like
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