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Oral supplementation of collagen peptides improves skin hydration by increasing the natural moisturizing factor content in the stratum corneum: a randomized, double-blind, placebo-controlled clinical trial
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Together, these changes significantly lower the analogs affinity for IGF-binding proteins the regulatory proteins that normally limit how much circulating IGF-1 reaches cellular receptors
10.1074/jbc.M101355200 J
Hydration changes appear sooner
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