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however, in the metabolic context created by concurrent GLP-1 and GIP activation (which provides the insulin response to counterbalance glucose effects), glucagon receptor activation primarily drives hepatic fat oxidation, increases resting energy expenditure, and promotes lipolysis from adipose tissue

SELENON, selenoprotein N

Injectable GLP-1 agonists are currently accessible to only a small fraction of this population, concentrated in high-income countries with strong pharmaceutical supply chains and insurance systems

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