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By August 2025, research from the RAND American Life Panel showed that approximately 11.8% of American adults (nearly 1 in 8 people) had used GLP-1 medications at least once, marking a dramatic increase in adoption

The combination produced greater weight loss, blunted the weight regain that often follows treatment, sustained glucose control and, notably, helped prevent the muscle (grip-strength) loss seen with the drug alone

Some also reported headaches, dizziness and fatigue

Most common adverse reactions (5%) for GIMOTI are: dysgeusia, headache, and fatigue

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