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These products are cleaved into glutamine, cysteine, and glycine under the action of 5-oxoalaninase and Cys-Gly peptidase, respectively, and then added to new GSH synthesis [32, 37] (summarized in Fig
Besides, it seems that behavioral phenotypes in the VPA model emerge from altered developmental trajectories rather than acute oxidative imbalance, which may explain why postnatal redox modulation failed to rescue sociability and exploratory behavior
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Microglial ferroptotic stress causes non-cell autonomous neuronal death