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Observational studies A large number of cross-sectional and prospective cohort studies have associated elevated blood homocysteine concentrations with measures of poor cognitive scores and increased risk of dementia, including Alzheimer's disease (reviewed in 67, 69)

Monthly B12 injections or high dose oral supplements (0.5 mg) can be prescribed to correct a diagnosed deficiency but many researchers feel that it is a good idea for everyone over the age of 50 to take a B12 supplement, which includes at least the daily value of 2.4 micrograms

If B12 levels are already within a normal range, additional B12 may not lead to noticeable changes in energy or performance

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