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Although the time course of Nrf2 stabilization and nuclear translocation indicated a rapid increase with a peak at approximately 6 h for DEM, and a slow but gradual rise triggered by NFT, maximal accumulation of Nrf2 protein, as well as the induction of GCLC and glutathione synthesis, were almost identical for both NFT and DEM after incubation periods of and beyond 24 h (Fig

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Foundational Pharmacology & Diet-Induced Obesity Study (Biochemical Pharmacology, 2018) Selective NNMT Inhibition Reverses Diet-Induced Obesity in Mice The foundational published study of 5-Amino-1MQs pharmacological characterisation and in vivo efficacy was published in Biochemical Pharmacology