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Although homocysteine is not obtained directly from food, it plays a central role in the methylation cycle as an intermediate in reactions that support normal cellular function

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It is then activated in the cytosol by hydrolysis (Aldossary, 2019

Abbreviations ADI: Italian Association of Dietetics and Clinical Nutrition BMI: Body Mass Index CVD: Cardiovascular Disease DASH: Dietary Approaches to Stop Hypertension EPA: Eicosapentaenoic Acid GLP- 1: Glucagon-Like Peptide-1 HDL: High-Density Lipoprotein HS: Hidradenitis Suppurativa IGF- 1: Insulin-Like Growth Factor 1 IL: Interleukin KeNuT: Ketogenic Nutritional Therapy LDL: Low-Density Lipoprotein MedDiet: Mediterranean Diet MetS: Metabolic Syndrome MNT: Medical Nutrition Therapy mTORC1: Mechanistic Target of Rapamycin Complex 1 PASI: Psoriasis Area Severity Index PUFA: Polyunsaturated Fatty Acid RCT: Randomized Controlled Trial ROS: Reactive Oxygen Species SIE: Italian Society of Endocrinology SINut: Italian Society of Nutraceuticals SIDeMaST: Italian Society of Dermatology and Sexually Transmitted Diseases TNF-: Tumor Necrosis Factor Alpha VLEKT: Very Low-Energy Ketogenic Therapy VLCKD: Very Low-Calorie Ketogenic Diet References Khan AQ, et al