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21 The methodical difficulty in this context consists of the large prevalence of disc degeneration in the asymptomatic population

This translocation is supported by Karyopherin 1 (importin 5), that functions as an adaptor molecule, and Karyopherin 1 (importin 1), the transport receptor that allows NRF2 translocation from the cytoplasm to the nuclear side of the NPC, due to Nuclear Localization Signal (NLS) sequences in NRF2 [160]

These are not interchangeable in mechanism

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