While effective for symptom control, NSAIDs carry risks of gastrointestinal ulceration and bleeding, cardiovascular events, renal impairment, and impaired bone and tendon healing
1) GLP-1: appetite control + slower digestion GLP-1 activation (the pathway used by semaglutide/Wegovy) helps people feel fuller sooner, reduces appetite, and slows gastric emptying often reducing snacking and lowering overall intake
Another clinical trial utilized NR to help ameliorate heart failure (HF), which is also characterized by a decline in NAD + levels in whole blood 317,318
A higher prescription rate of GLP-1s among people with private insurance points to "socioeconomic factors," the study reads
Current Safety Evidence and Clinical Trial Data Known Side Effects and Risks to Be Aware Of Who Should Avoid Retatrutide or Use It With Caution Retatrutide's Regulatory Status in the UK Speaking to Your GP or Specialist Before Starting Treatment Scientific References Frequently Asked Questions What Is Retatrutide and How Does It Work