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Though most GLP-1RAs are approved only for T2D, semaglutide and liraglutide are also approved for weight loss likely driven by GLP-1RAs actions on satiety and gastric emptying

As we age, production of both proteins declines significantly while degradation accelerates

Stress-Response & Adaptation Research: Examining signaling pathways related to stress-response modulation, neuroendocrine balance, and adaptive system regulation

Affiliate Professor at UTEP

Keywords , MASH , GLP-1 receptor agonists , hepatic steatosis , metabolic dysfunction , tirzepatide , semaglutide , survodutide 0 2 INTRODUCTION Metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed nonalcoholic fatty liver disease (NAFLD), has emerged as the predominant hepatic pathology worldwide, impacting roughly twenty-five percent of the adult population [1,2]