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Endogenous plasma concentrations decline from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60, a reduction that correlates with diminished tissue remodeling capacity
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Concretely, GPX4 uses GSH as the substrate to reduce phospholipid hydroperoxides (PLOOHs) to hydroxyl derivatives (PLOHs), and oxidizes GSH to GSSH, therefore alleviating the damage of oxidative stress to tumor cells (Stockwell, 2022)
People with cystinuria are naturally more likely to form cystine kidney stones
in the context of cancer cell pyroptosis, pattern recognition receptors help sense damage-associated molecular patterns released from pyroptotic tumour cells and shape downstream antitumour immune responses
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