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Both primary and secondary hypogonadism present with persistent low levels of testosterone, but primary hypogonadism is also associated with elevated luteinizing hormone (LH) while secondary hypogonadism may present with low or normal LH

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50,51 Overall, SIRT1 functions as a key metabolic sensor and epigenetic regulator, with both expression and enzymatic activity finely tuned by internal and external cellular signals

JC virus T-antigen regulates glucose metabolic pathways in brain tumor cells